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Latest research study on coronavirus reveals unknown facts!   

COVID – 19, has set two and odd countries on fire with the raging death roars in every country. Researchers are on constant observation and study to find out the loophole of the virus to help develop a vaccine to eradicate the same.

The common human cold and common respiratory infections in the other species, bats in this case including the livestock poultry are subject to coronavirus.


The political birth of coronavirus:

Ever since it crossed the barrier between infecting the human species from animals, several veterinary and biomedical scientists have been called on to share their considerable knowledge of coronaviruses.

They then research which claimed that the coronavirus was just another basic common cold disease stands a tall lie today.  The experience of the COVID 19 patients who were discharged after the infection is surmount in response.

This experience is severe.  It is highly evident in available knowledge and understanding of coronavirus biology and molecular biology.

Viruses have been detected in wild mammals of southern China that were brought to marketplaces where they were sold as exotic food.


The mutation:

The tendency of coronaviruses to undergo mutation and recombination represents a significant challenge for vaccine development.

With all the study, till date there is no vaccine that cures the severe cut throat pandemic, coronavirus.  Nor a vaccine that can provide a long-term protection against respiratory coronavirus infections.

Genetic approaches represent the best hope of overcoming this propensity for mutability, according to world-class workshop experts.

 For example, it might be possible to find ways to limit RNA-RNA homologous recombination, or to identify areas in the genome (GENES) that are more or less prone to survive mutation. Mutation is subjective to blood group too? We shall find out.

Promising approaches to these challenges include the use of reverse molecular genetics to make specific mutations in the virus genome and test their functional effects. Smart yet common logic for the experts to study and find the structure.

The finding that the coronavirus mutates into two strains with the L strain leading to more severe disease “is most likely a statistical artifact,” Richard Neher, a biologist and physicist at the University of Basel in Switzerland, wrote on Twitter.

This statistical effect is probably due to early sampling of the L group in Wuhan, resulting in a “higher apparent” case fatality rates, he wrote.


The structures matter:

The researchers found the “L” type, which they deemed the more aggressive type, in 70% of the virus samples. They also found that the prevalence of this strain decreased after early January.

The more commonly found type today is the older, “S” type, because “human intervention” such as quarantines may have reduced the ability of the “L” type to spread, researchers wrote in the paper.


The Grubaugh note:

However, Nathan Grubaugh, an epidemiologist at the Yale School of Public Health who was not part of the study, said the authors’ conclusions are “pure speculation.”

For one thing, he said, the mutations the study authors referenced were incredibly small — on the order of a couple of nucleotides, the basic building blocks of genes, he said. (SARS-CoV-2 is about 30,000 nucleotides long) (I nucleotide = Five carbon ribose sugar, 2) a phosphate molecule and 3) one of four nitrogenous bases: adenine, guanine, cytosine or uracil).

These slight changes likely wouldn’t have a major impact, if any at all, on the functioning of the virus, so it would be “inaccurate” to say that these differences mean there are different strains, he said. In addition, the researchers looked at only 103 cases.

“It’s a very small sample set of the total virus population,” Grubaugh told Live Science. Figuring out the mutations that a virus underwent worldwide takes “a nontrivial amount of effort and sometimes takes years to complete,” he said.


Other scientists agree with this author.




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